# Nonlinear Mixed Effects Models in Population PK/PD

## Documentation for package ‘nlmixr2’ version 3.0.0

- DESCRIPTION file.
- Package NEWS.

## Help Pages

addCwres | Add CWRES
addNpde | NPDE calculation for nlmixr2
addTable | Add table information to nlmixr2 fit object without tables
bobyqaControl | Control for bobyqa estimation method in nlmixr2
bootplot | Produce delta objective function for boostrap
bootstrapFit | Bootstrap nlmixr2 fit
covarSearchAuto | Stepwise Covariate Model-selection (SCM) method
foceiControl | Control Options for FOCEi
lbfgsb3cControl | Control for lbfgsb3c estimation method in nlmixr2
n1qn1Control | Control for n1qn1 estimation method in nlmixr2
newuoaControl | Control for newuoa estimation method in nlmixr2
nlmControl | nlmixr2 defaults controls for nlm
nlmeControl | Control Values for nlme Fit with extra options for nlmixr
nlminbControl | nlmixr2 nlminb defaults
nlmixr2 | nlmixr2 fits population PK and PKPD non-linear mixed effects models.
nlmixr2CheckInstall | Check your nlmixr2 installation for potential issues
nlsControl | nlmixr2 defaults controls for nls
optimControl | nlmixr2 optim defaults
preconditionFit | Linearly re-parameterize the model to be less sensitive to rounding errors
profileFixed | Estimate the objective function values for a model while fixing defined parameter values
profileFixedSingle | Estimate the objective function values for a model while fixing defined parameter values
profileLlp | Profile confidence intervals with log-likelihood profiling
saemControl | Control Options for SAEM
setOfv | Set/get Objective function type for a nlmixr2 object
tableControl | Output table/data.frame options
traceplot | Produce trace-plot for fit if applicable
uobyqaControl | Control for uobyqa estimation method in nlmixr2
vpcCens | VPC based on ui model
vpcCensTad | VPC based on ui model
vpcPlot | VPC based on ui model
vpcPlotTad | VPC based on ui model
vpcSim | VPC simulation