POSPS {yeastGSData} | R Documentation |
While Yu et al. call this a platinum standard data set, it is really a gold standard data set for binary physical interactions.
data(POSPS)
A data frame with 1867 observations on the following 2 variables.
ORF1
ORF2
These data, reported in the paper below, are intended to represent well
established binary physical interactions between proteins. This contrasts
with the gold standard MIPSGS
which describes
multi-protein complexes.
Ye et al, describe the construction as follows: “ Briefly, the data set contains physical interactions from complex protein structures in the Protein Data Bank (Westbrook et al. 2003), verified interactions from small-scale experiments (Mewes et al. 2000; Xenarios et al. 2002; Bader et al. 2003), and protein pairs from small MIPS catalog complexes (4 or fewer subunits).”
Annotation Transfer Between Genomes: Protein-Protein Interologs and Protein-DNA Regulogs, H. Yu et al, Genome Research, 1107-1118, 2004.
data(POSPS)